| Huntsville API manufacturing plant (Greenbrier South)Eli Lilly and Company, Huntsville, Alabama | December 10, 2025Announced | $6.0B | madeinalabama.com |
| Chesapeake copper rod, magnet wire and rare-earth magnet complexLS Cable & System Ltd., Chesapeake, Virginia | December 12, 2025Announced | $689M | vedp.org |
| Salt Lake City neurovascular manufacturing expansionStryker, Salt Lake City, Utah | December 11, 2025Announced | $616M | business.utah.gov |
| Rockville biologics drug substance plant (acquired from GSK, expansion)Samsung Biologics, Rockville, Maryland | December 29, 2025Announced | $280M | commerce.maryland.gov |
| Norton siRNA manufacturing plant expansionAlnylam Pharmaceuticals, Inc., Norton, Massachusetts | December 17, 2025Announced | $250M | businesswire.com |
| Philadelphia Bellwether District canned beverage manufacturing facilityDrinkPAK, Philadelphia, Pennsylvania | December 8, 2025Announced | $195M | pa.gov |
| Louisville precision parts manufacturing facilityFoxconn Technology USA Corp. (Foxconn Technology Co. Ltd.), Louisville, Kentucky | December 9, 2025Announced | $173M | newkentuckyhome.ky.gov |
| Jacksonville automated pouch operation manufacturing expansionSwisher, Jacksonville, Florida | December 11, 2025Announced | $135M | jaxusa.org |
| Sioux City honey processing plantSioux Honey Association, Sioux City, Iowa | December 19, 2025Announced | $130M | opportunityiowa.gov |
| Orangeburg ladder frame plantSODECIA AAPICO Joint Venture, Orangeburg, South Carolina | December 2, 2025Announced | $120M | sccommerce.com |
| Halls aluminum manufacturing plant (former Tupperware building)ALUKO Group, Halls, Tennessee | December 17, 2025Announced | $108M | tn.gov |
| Bowling Green aluminum extrusion and finishing plant (Kentucky Transpark)AKFA Aluminum Solutions U.S. LLC, Bowling Green, Kentucky | December 15, 2025Announced | $80M | kentucky.gov |
| Laurel poultry processing plant expansionAmick Farms, Laurel, Mississippi | December 15, 2025Announced | $75M | mississippi.org |
| Detroit defense manufacturing facilityEccalon, Detroit, Michigan | December 9, 2025Announced | $71M | michigan.gov |
| Henrico power distribution equipment campusEaton, Henrico, Virginia | December 10, 2025Announced | $50M | vedp.org |
| Wheatland Township cultured dairy plant expansionMichigan Milk Producers Association, Wheatland Township, Michigan | December 9, 2025Announced | $38M | michigan.gov |
| Ovid ultrafiltered milk plant expansionMichigan Milk Producers Association, Ovid, Michigan | December 9, 2025Announced | $33M | michigan.gov |
| Wixom collaborative robot manufacturing expansionTeradyne, Wixom, Michigan | December 9, 2025Announced | $32M | michigan.gov |
| Shreveport data center equipment manufacturing expansionSLB, Shreveport, Louisiana | December 9, 2025Announced | $30M | opportunitylouisiana.gov |
| Montpelier brass mill expansionWieland Chase, LLC (Wieland Group), Montpelier, Ohio | December 15, 2025Announced | $28M | jobsohio.com |
| Livingston pipe fabrication expansion (large-diameter line)Epic Piping, LLC, Livingston, Louisiana | December 10, 2025Announced | $25M | opportunitylouisiana.gov |
| Davenport foodservice equipment plant expansionH.C. Duke & Son (Electro Freeze), Davenport, Iowa | December 19, 2025Announced | $7M | opportunityiowa.gov |
| Colquitt pavement marker plantGrupo Vialume, Colquitt, Georgia | December 11, 2025Announced | $4M | georgia.org |