| Houston API facility, Generation ParkEli Lilly and Company, Houston, Texas | September 23, 2025Announced | $6.5B | investor.lilly.com |
| Richmond-area ADC / API facilityEli Lilly and Company, Goochland County (West Creek), Virginia | September 16, 2025Announced | $5.0B | investor.lilly.com |
| Alabama River Cellulose mill modernization and expansionGeorgia-Pacific (GP Cellulose), Perdue Hill, Alabama | September 10, 2025Announced | $800M | madeinalabama.com |
| South Boston large power transformer facilityHitachi Energy, South Boston, Virginia | September 4, 2025Announced | $457M | governor.virginia.gov |
| Prattville laminate shingle plantOwens Corning, Prattville, Alabama | September 19, 2025Announced | $325M | madeinalabama.com |
| Columbus rare earth permanent magnet plantJS Link America Inc. (JS Link), Columbus, Georgia | September 3, 2025Announced | $223M | georgia.org |
| Spartanburg County flight-control actuation plant (Smith Farms Industrial Park)Woodward, Inc., Greer, South Carolina | September 16, 2025Announced | $200M | governor.sc.gov |
| Salt Lake City rail vehicle plant expansionStadler US, Salt Lake City, Utah | September 11, 2025Announced | $189M | business.utah.gov |
| Northborough materials plant expansionSaint-Gobain Ceramics & Plastics Inc., Northborough, Massachusetts | September 17, 2025Announced | $120M | mass.gov |
| Iron County rocket motor additives plant expansionAmerican Pacific Corporation (AMPAC), Cedar City, Utah | September 11, 2025Announced | $100M | business.utah.gov |
| Billerica advanced manufacturing expansionEntegris Inc., Billerica, Massachusetts | September 17, 2025Announced | $100M | mass.gov |
| Washington transformer plant expansionWEG Transformers USA, Washington, Missouri | September 23, 2025Announced | $77M | ded.mo.gov |
| Tin Ridge tin refining plantNathan Trotter, Martinsville area, Virginia | September 9, 2025Announced | $65M | governor.virginia.gov |
| Cedar City PVC pipe and fittings plantPPI America Inc., Cedar City, Utah | September 11, 2025Announced | $52M | business.utah.gov |
| Tradepoint Atlantic spiralweld steel pile millJD Fields HDM Spiralweld Mill, LLC (JD Fields & Company / HDM Steel Pipe), Sparrows Point, Maryland | September 16, 2025Announced | $50M | commerce.maryland.gov |
| New Braunfels blow molding plantLefko USA Inc., New Braunfels, Texas | September 30, 2025Announced | $15M | gov.texas.gov |